Natasha Rozenkrants Selected Research

4- ((2- cyclobutyl- 1H- imidazo(4,5- b)pyrazin- 1- yl)methyl)- 7,8- difluoroquinolin- 2(1H)- one

2/2011	Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
11/2010	Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
5/2009	Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

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Natasha Rozenkrants Research Topics

Disease

4	Pain (Aches) 02/2011 - 05/2009
2	Autoimmune Diseases (Autoimmune Disease) 12/2016 - 08/2014
2	Inflammation (Inflammations) 12/2016 - 01/2012
2	Neuralgia (Stump Neuralgia) 11/2010 - 05/2009
1	Rheumatoid Arthritis 12/2016
1	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2016
1	Edema (Dropsy) 02/2011
1	Hyperalgesia 02/2011
1	Endotoxemia 07/2009

Drug/Important Bio-Agent (IBA)

4	Formaldehyde (Formol)FDA Link 02/2011 - 05/2009
3	4- ((2- cyclobutyl- 1H- imidazo(4,5- b)pyrazin- 1- yl)methyl)- 7,8- difluoroquinolin- 2(1H)- oneIBA 02/2011 - 05/2009
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2012 - 02/2011
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 02/2011 - 05/2009
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 02/2011 - 11/2010
2	QuinolonesIBA 11/2010 - 05/2009
1	Interleukin-23 (Interleukin 23)IBA 12/2016
1	CytokinesIBA 12/2016
1	Interleukin-17 (Interleukin 17)IBA 12/2016
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 08/2014
1	EnzymesIBA 01/2012
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2012
1	Biological ProductsIBA 01/2012
1	Pregabalin (Lyrica)FDA Link 02/2011
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 02/2011
1	Celecoxib (Celebrex)FDA Link 02/2011
1	Gabapentin (Neurontin)FDA LinkGeneric 02/2011
1	phenylbenzoquinoneIBA 02/2011
1	Capsaicin (Zostrix)FDA Link 02/2011
1	CarrageenanIBA 02/2011
1	benzimidazoleIBA 11/2010
1	N- (3- chlorophenyl)- N- ((8- fluoro- 2- oxo- 1,2- dihydroquinolin- 4- yl)methyl)- 4- methylthiazole- 5- carboxamideIBA 07/2009

Therapy/Procedure

1	Ligation 02/2011
1	Oral Administration 07/2009